Table 3.
Modulation of DMBA induced impairment of detoxification enzymes by betulinic acid among different treatment groups of female Sprague Dawley rats.
| Parameter | Group I | Group II | Group III | Group IV | Group V | Group VI | F-ratio | HSD value |
|---|---|---|---|---|---|---|---|---|
| Glutathione-S-transferase | ||||||||
| (milli IU/mg protein) | ||||||||
| Stomach | 8.010a±0.003 | 5.870b±0.004 | 2.320c±0.002 | 2.050d±0.001 | 1.220e±0.001 | 5.140f±0.0028 | 89.988* | 0.00407 |
| Lung | 3.911a±0.006 | 9.665b±0.0018 | 2.346c±0.0063 | 2.849d±0.007 | 7.991e±0.005 | 2.123f±0.0018 | 14.349* | 0.00839 |
| DT- diaphorase | ||||||||
| (μmol IU/mg protein) | ||||||||
| Stomach | 106.70a±0.085 | 407.10b±0.085 | 361.40c±0.086 | 541.50d±0.286 | 330.10e±0.171 | 679.20f±0.085 | 10.537* | 0.006924 |
| Lung | 319.160±1.714 | 431.040±0.100 | 408.730±0.571 | 268.340±0.571 | 254.40±0.541 | 278.933±1.142 | 2.944 | - |
*Represents significance at P≤0.05. Superscripts a-f represents comparison of group I, II, III, IV, V and VI means using HSD value.