Table 5.
Modulation of DMBA induced impairment of oxidative stress parameters by betulinic acid among different treatment groups of female Sprague Dawley rats.
| Parameter | Group I | Group II | Group III | Group IV | Group V | Group VI | F-ratio | HSD value |
|---|---|---|---|---|---|---|---|---|
| Lipid Peroxidation (TBARS) | ||||||||
| (μmoles MDA equivalent/g of tissue) | ||||||||
| Stomach | 117.913a±0.003 | 119.632b±0.002 | 139.983c±0.006 | 65.728d±0.009 | 110.762e±0.008 | 121.213f±0.01 | 20.021* | 0.0384 |
| Lung | 19.594a±0.001 | 44.483b±0.017 | 29.564c±0.007 | 42.971d±0.003 | 15.675e±0.006 | 43.315f±0.004 | 3.113* | 0.0503 |
| Lipid Hydroperoxides | ||||||||
| (mM H2O2 equivalents/g of tissue) | ||||||||
| Stomach | 1.582±0.004 | 0.730±0.01 | 4.077±0.012 | 1.345±0.013 | 1.906±0.017 | 2.190±0.009 | 0.1445 | - |
| Lung | 2.522a±0.006 | 0.983b±0.004 | 2.924c±0.006 | 1.367d±0.008 | 1.767e±0.002 | 1.401d±0.021 | 8.017* | 0.0558 |
| Reduced Glutathione | ||||||||
| (μM of SH content/g of tissue) | ||||||||
| Stomach | 764.130a±0.001 | 523.460b±0.002 | 1895.310c±0.010 | 1744.88d±0.003 | 625.750e±0.001 | 1143.20f±0.002 | 4.659* | 0.0216 |
| Lung | 1186.610±0.008 | 983.770±0.002 | 2216.02±0.008 | 2190.0±0.002 | 1222.110±0.002 | 1566.930±0.003 | 0.6193 | - |
| Protein Content | ||||||||
| (mg/g of tissue) | ||||||||
| Stomach | 40.140a±0.043 | 17.540b±0.02 | 67.180c±0.02 | 39.420d±0.007 | 135.020e±0.033 | 27.340f±0.006 | 71.401* | 0.1194 |
| Lung | 63.916a±0.005 | 57.233b±0.004 | 30.166c±0.011 | 54.816d±0.002 | 41.033e±0.001 | 61.233f±0.031 | 20.114* | 0.0832 |
*Represents significance at P≤0.05. Superscripts a-f represents comparison of group I, II, III, IV, V and VI means using HSD value.