Table 4. Relationships of WMH and LI with the incidence of AD according to age.
| 60–69 years | 70–79 years | ≥80 years | ||||
|---|---|---|---|---|---|---|
| n* | Incidence per 1,000 person-years (95% CI) | n* | Incidence per 1,000 person-years (95% CI) | n* | Incidence per 1,000 person-years (95% CI) | |
| WMH and LI | ||||||
| Neither WMH nor LI | 21 | 10 (5–16) | 18 | 12 (10–19) | 10 | 21 (13–28) |
| Only WMH | 65 | 26 (14–39) | 48 | 34 (21–47) | 34 | 45 (28–65) |
| Only LI | 32 | 25 (19–38) | 31 | 33 (21–45) | 17 | 40 (22–65) |
| Both WMH and LI | 36 | 31 (21–49) | 23 | 42 (27–58) | 22 | 58 (32–74) |
| Only WMH | ||||||
| Mild | 24 | 21 (16–29) | 21 | 29 (18–41) | 14 | 37 (22–52) |
| Moderate | 25 | 32 (23–44) | 14 | 38 (25–54) | 11 | 49 (31–64) |
| Severe | 16 | 39 (25–53) | 13 | 46 (27–64) | 9 | 57 (38–72) |
| Only LI | ||||||
| A few (1 to 3) | 19 | 20 (12–29) | 18 | 31 (15–47) | 8 | 35 (19–52) |
| Many (≥4) | 13 | 34 (21–47) | 13 | 39 (27–51) | 9 | 51 (33–69) |
| Total | 154 | 19 (11–34) | 120 | 28 (16–41) | 83 | 38 (21–53) |
*The number of AD cases.
AD: Alzheimer's disease, LI: lacunar infarcts, WMH: white-matter hyperintensities.