Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Oct 10;34(1):146–155. doi: 10.3904/kjim.2016.298

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 The Korean Association of Internal Medicine

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 2. — Effect of paricalcitol treatment on expression of pro-/anti-apoptotic Bcl-2-associated protein X (Bax)/B-cell lymphoma 2 (Bcl-2) in indoxyl sulfate (IS)-treated human renal proximal tubular epithelial (HK-2) cells. (A) Incubation with IS for 3, 6, 12, or 24 hours increased the ratio of Bax/Bcl-2 expression. (B) The increased Bax/Bcl-2 ratio was counteracted by treatment with paricalcitol (5 ng/mL). (C) HK-2 cells treated with 1 mM IS for 24 hours exhibited a progressive increase in Annexin V positive staining, which was counteracted by paricalcitol treatment. GAPDH, glyceraldehyde-3-phosphate dehydrogenase. ^ap < 0.05 vs. control, ^bp < 0.05 vs. IS-treated HK-2 cells.