Figure 4.

Effects of co-treatment on migration and invasion of PC cells. A. Co-treatment inhibited cell migration of PANC-1 and MIA PaCa-2 cells in the wound-healing migration assay. Photographs were taken at o h and 48 h, after the wound was made. (*P < 0.05, **P < 0.01, ***P < 0.001). B. Migration and invasion assay of PANC-1 and MIA PaCa-2 cells treated with CUDC-101 and/or gemcitabine for 48 h, and the number of migrate and invasive cells were determined using a transwell penetration assay. (*P < 0.05, **P < 0.01, ***P < 0.001).