Figure 6.

The PDE4D mRNA is down-regulated in colorectal cancer compared with colon as revealed by oncomine data-mining analysis and PDE4D lower expression group had a poorer overall survival rate. A. Down-regulation of PDE4D was found in 11 of 20 cancer types. B. Level of PDE4D mRNA was significantly decreased from colon to CRC with probe (204491_at) in the kaiser’s dataset. C. The expression level of PDE4D mRNA was significantly decreased from colon, rectum to CRC in probe (A_24_P419353) in TCGA dataset. D. PDE4D lower expression group had a poorer overall survival rate (P < 0.05) in COAD (Colon adenocarcinoma) and READ (Rectum adenocarcinoma) datasets on gepia.cancer websites.