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Downregulation of HIF-1α was dependent on the PI3K/Akt pathway. (A) Western blot of HIF-1α, total Akt and phosphorylated Akt (p-Akt) after treatment with IGF-1, LY294002, and quercetin; (B and C) are histograms indicating the relative quantities of HIF-1α and p-Akt protein. HIF-1α expression decreased along with protein level of p-Akt in the LY294002 and quercetin treated groups, and IGF-1 was able to attenuate suppression of HIF-1α. (*, P<0.05; **, P<0.01).
