Figure 1.

ISL ameliorated LPS-induced AKI renal dysfunction in mouse model. A. The formula of Isoliquiritigenin (ISL). B and C. LPS increased the CREA and BUN which represent serious kidney inflammation. ISL can decrease CREA and BUN to protect renal function. The level of CREA and BUN was measured by assay kit. D. Histological changes were assessed using HE and PAS staining. LPS treatment induced severe renal pathological lesions compared to normal control mice. In contrast, ISL treatment reduced the pathological features in murine kidney (magnification, ×400); *P < 0.05 vs. the LPS group, ***P < 0.001 vs. the LPS group, ###P < 0.001 vs. the Ctrl group.