Systolic blood pressure measured by tail-cuff plethysmography 35 weeks after RDN performed at the age of 13 weeks. Asterisk indicates statistical significance (P < 0.01) vs sham operated rats; NS, not significant; Values are mean ± standard deviation; N = 10 in each group; WKY-Sham indicates sham-operated Wistar-Kyoto rats; WKY-RDN, Wistar-Kyoto rats subjected to renal denervation; SHR-Sham, sham-operated spontaneously hypertensive rats, SHR-RDN, spontaneously hypertensive rats subjected to renal denervation.