Table 4.
The meta-analyses of associations between anemia and mCRPC
| Group | Subgroup | Studies number | Sample size | HR (95% CI) | I2 (%) | Begg | Egger |
|---|---|---|---|---|---|---|---|
| Prognostic (OS) | NA | 3 | 3177 | 1.55 (1.24, 1.94) | 60.6 | 0.456 | 0.792 |
| Prognostic (PFS) | NA | 2 | 1502 | 1.47 (1.22, 1.75) | 0 | NA | NA |
| Retrospective (OS) Before sensitivity analysis | Total | 7 | 1666 | 1.63 (1.25, 2.13) | 75 | 1 | 0.011 |
| Caucasian | 3 | 807 | 2.00 (1.56, 2.56) | 0 | 1 | 0.31 | |
| Asian | 3 | 474 | 1.64 (1.27, 2.13) | 0 | 1 | 0.768 | |
| Mixed | 1 | 379 | 1.15 (1.07, 1.24) | NA | NA | NA | |
| Retrospective (OS) after sensitivity analysis | NA | 6 | 1287 | 1.82 (1.52, 2.18) | 0 | 1 | 0.653 |
| Retrospective (CSS) | NA | 1 | 145 | 1.47 (0.55, 3.99) | NA | NA | NA |
HR, hazard ratio; OS, Overall survival ; PFS, Progression free survival; CSS, Cause-Specific Survival; NA, Not available.