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. 2018 Dec 10;5(6):ENEURO.0422-18.2018. doi: 10.1523/ENEURO.0422-18.2018

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Copyright © 2018 Bercovici et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 4. — Inhibition of BLA→NAc pathway following rewarded outcomes and during ITI. A, Optogenetic manipulation and task design. Top, Inhibition during large rewards occurred on trials the large/risky lever was chosen and reward was delivered. Bottom, Inhibition during small rewards occurred on trials immediately after the small/certain lever was chosen. B, C, Inhibition of pathway during either large/risky wins (n = 14) or small/safe wins (n = 14) shows no reliable change in choice. D, Optogenetic manipulation during ITI. Light was delivered during every ITI, starting 6–12 s after the end of a trial. E, Optogenetic inhibition during the ITI did not alter choice (n = 12).