Figure 9.

Tissue and nerve injury-induced hypersensitivity in BDNF-cKO mice. A, Tamoxifen-treated cKO animals developed normal mechanical allodynia one week after SNI. B, Mechanical allodynia also did not differ between tamoxifen- and corn oil-treated mice in a paclitaxel-induced chemotherapy model of neuropathic pain. C, Unexpectedly, female control mice developed greater thermal hypersensitivity 12 d after paclitaxel compared to male groups. While this hypersensitivity decreased after tamoxifen-treatment, it did not do so significantly (p > 0.05). Mechanical allodynia (D) and thermal hypersensitivity (E) also did not differ between BDNF cKO and control mice 3 d after CFA injection. Data are mean ± SEM. For A, B, D, E, statistical significance was determined by Student’s t test. For C, statistical significance was determined by two-way ANOVA with Bonferroni correction for multiple comparisons; *p < 0.05. Numbers of animals are indicated on graphs.