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. 2018 Nov 8;6(1):1801260. doi: 10.1002/advs.201801260

Figure 5.

Figure 5

Effect of silicon‐enriched ion extract on VEGF‐mediated angiogenesis of NRCMs and HUVECs co‐cultures under glucose/oxygen deprived conditions in vitro. a) Representative fluorescence images of vWF‐stained tube formation of co‐HUVECs under glucose/oxygen deprived conditions in vitro. Scale bars represent 75 µm. b) Quantification of tune numbers in coculture systems (10 pictures for each group). *p < 0.01 versus PBS group; mean ± SD. c) Gene expression of VEGFA in mono and co‐NRCMs under glucose/oxygen deprived conditions. d) Gene expression of VEGF165 in mono and co‐HUVECs under glucose/oxygen deprived conditions. e) Gene expression of KDR in mono‐ and co‐HUVECs under glucose/oxygen deprived conditions for 120 min; *p < 0.05 versus PBS group. **p < 0.01 versus mono‐cultured PBS group; †p < 0.05 versus cocultured PBS. Data are obtained from three independent experiments; mean ± SD.