Figure 4.

A porous and degradable scaffold for personalized wound treatment. a) Polymeric microparticles were prepared by microfluidics, incorporating a metalloprotease‐degradable peptide as cross‐linkers. The water‐in‐oil approach segmented the monomers and crosslinkers into monodispersed droplets, which were then crosslinked inside the droplets. b) The microparticles were further purified and annealed with FXIIIa to form porous scaffolds that can support cell growth. c) The induction of in vivo wound healing by the engineered scaffold for 7 days. Shown are the representative wound healing images from Balb/c mice. The microparticle‐based porous scaffold induced much faster wound healing than other materials. Reproduced with permission.89 Copyright 2015, Springer Nature.