Figure 5.

A closed‐loop drug delivery system that enables precise dosing of insulin according to the blood sugar level of the patient. a) Schematics of the drug delivery device; polymeric micelles that could release insulin in response to blood sugar levels were formulated into microneedles for painless delivery. b) Fluorescent microscope image of the microneedle patch. c) Glucose‐responsive insulin release from the microneedle patch in vitro. d) The insulin delivery patch kept blood glucose levels within a normal range for an extended range of time. Reproduced with permission.108 Copyright 2015, National Academy of Sciences.