Table II.

E-cadherin thresholds of positivity and correlations with clinical-histopathological parameters.

Authors	E-cadherin assay	E-cadherin location	Cutoff level	Clinical and histopathological investigated parameters
				T	N	Stage	Grade	DFS/DSS	OS
Rodrigo et al. 23	IHC	C-M	Score	No	Yes	N/E	No	No	N/E
Zou et al. 33	IHC	C	Score	Yes	Yes	N/E	Yes	Yes	N/E
Paksoy et al. 25	IHC	n/a	> 75%	N/E	No	N/E	N/E	N/E	N/E
Li et al. 6	IHC	C-M	Score	N/E	Yes	N/E	N/E	Yes	Yes
Carico et al. 29	IHC	M	Score	N/E	N/E	N/E	Yes	No	N/E
Akdeniz et al. 26	IHC	C-M	Score	N/E	Yes	No	Yes	N/E	N/E
Ahmed et al. 27	IHC	C-M	> 50%	N/E	Yes	Yes	Yes	Yes	N/E
Psyrri et al. 34	IHC	C-M	Score	No	No	No	No	Yes	No
Greco et al. 30	IHC	C-M	> 50%	N/E	N/E	N/E	N/E	Yes	Yes
Ali Bayram et al. 35	IHC	n/a	> 25%	No	No	No	No	N/E	N/E
Cappellesso et al. 28	IHC	M	Score	N/E	No	N/E	N/E	Yes	N/E
Barutçu et al. 36	IHC	n/a	> 50%	No	No	No	No	No	No
Qian et al. 31	IHC	C-M	> 20%	No	No	No	No	N/E	Yes

IHC: immunohistochemistry; M: membrane; C: cytoplasmic; DFS: disease free survival; DSS: disease specific survival; OS: overall survival; YES: significant correlation; NO: no significant correlation; n/e: not evaluated.