Table 1.
Variable | Neither steroid nor IVIG | Steroid alone* | IVIG alone | P‡ |
---|---|---|---|---|
Number of patients | 1342 | 105 | 95 | – |
Male gender—no. (%) | 713 (53.1) | 57 (54.3) | 62 (65.3) | 0.072 |
Age (year) | 2.9 ± 2.6 | 2.6 ± 2.9 | 1.9 ± 2.1 | < 0.001 |
Age group—no. (%) | < 0.001 | |||
< 1 yrs. | 394 (29.4) | 44 (41.9) | 39 (41.1) | |
1~2 yrs. | 432 (32.2) | 33 (31.4) | 42 (44.2) | |
3~5 yrs. | 337 (25.1) | 12 (11.4) | 7 (7.4) | |
6~11 yrs. | 179 (13.3) | 16 (15.2) | 7 (7.4) | |
Oral Medication—no. (%) | ||||
ACEi/ ARB | 66 (4.9) | 10 (9.5) | 5 (5.3) | 0.131 |
Beta blocker | 58 (4.3) | 6 (5.7) | 4 (4.2) | 0.723 |
Digoxin | 66 (4.9) | 14 (13.3) | 6 (6.3) | 0.003 |
Loop diuretics | 50 (3.7) | 15 (14.3) | 6 (6.3) | < 0.001 |
Potassium-sparing diuretics | 9 (0.7) | 4 (3.8) | 1 (1.1) | 0.017 |
Intravenous agents—no. (%) | ||||
Dobutamine | 68 (5.1) | 32 (30.5) | 13 (13.7) | < 0.001 |
Milrinone | 31 (2.3) | 7 (6.7) | 11 (11.6) | < 0.001 |
Dopamine | 127 (9.5) | 40 (38.1) | 23 (24.2) | < 0.001 |
Norepinephrine | 4 (0.3) | 2 (1.9) | 0 (0.0) | 0.104 |
Examination—no. (%) | ||||
Cardiac MRI | 18 (1.3) | 5 (4.8) | 9 (9.5) | < 0.001 |
Cardiac biopsy | 1 (0.1) | 1 (1.0) | 0 (0.0) | 0.243 |
Virus detection | 404 (30.1) | 53 (50.5) | 40 (42.1) | < 0.001 |
Severity assessment—no. (%) | ||||
VT/VF | 9 (0.7) | 1 (1.0) | 1 (1.1) | 0.428 |
CPR | 38 (2.8) | 12 (11.4) | 6 (6.3) | < 0.001 |
Bradycardia | 13 (1.0) | 2 (1.9) | 1 (1.1) | 0.489 |
Cardioversion | 20 (1.5) | 6 (5.7) | 4 (4.2) | 0.005 |
Temporary Pacemaker | 11 (0.8) | 2 (1.9) | 0 (0.0) | 0.375 |
ICU stay | 304 (22.7) | 65 (61.9) | 28 (29.5) | < 0.001 |
‡ Fisher’s exact test for categorical variable or one-way ANOVA for continuous variable;
*Steroid alone: those patients received high-dose steroid therapy
Abbreviations: ACEi angiotensin-converting enzyme inhibitor), ARB angiotensin receptor blocker, CPR cardiopulmonary resuscitation, ICU intensive care unit, IVIG intravenous immunoglobulin, MRI magnetic resonance imaging, VT/VF ventricular tachycardia/ventricular fibrillation