Table 1. Functions of Pif1 family helicases.
| Pif1 | Rrm3 | Pfh1 | |
|---|---|---|---|
| Replication fork progression | |||
| tDNAs | B (1) | Y (2) | Y (3) |
| G4 motifs | Y (4) | B (5) | Y (6) |
| Centromeres | B (7) | Y (2) | NT |
| Telomeres | (N) | Y (8) | Y (9) |
| RFB | N (10) | Y (10) | Y (3) |
| Support RFB | Y (10) | N (10) | N (3) |
| Separate converged forks | Y (11) | Y (10, 12) | Y (3, 13) |
| Maintain mtDNA | Y (14) | N | Y (15) |
| Inhibit telomerase | Y (16) | N (8) | N (9) |
| Promote BIR | Y (17) | N (17) | NT |
| Process Okazaki fragments | Y (18) | Y (19) | NT |
References used: (1) Tran et al. 2017; Osmundsen et al. 2017; (2) Ivessa et al. 2003; (3) Sabouri et al. 2012; (4) Paeschke et al. 2011; Lopes et al. 2011; (5) Paeschke et al. 2013; (6) Sabouri et al. 2014; (7) This paper; (8) Ivessa et al. 2002; (9) McDonald et al. 2014; (10) Ivessa et al. 2000; (11) K. Labib, personal communication; (12) Fachinette et al. 2010; (13) Steinacher et al. 2012; (14) Foury and Kolodynski 1983; (15) Pinter et al. 2008; (16) Zhou et al. 2000; (17) Saini et al. 2003; Wilson et al. 2013; (18) Budd et al. 2006; and (19) Osmundsen et al. 2017. B, Backup role; Y, Yes; NT, not tested; (N), probably no; RFB, replication fork barrier; N, NO; BIR, break-induced replication.