Table 4.
The relationship of seven 3′UTR polymorphisms with lung cancer according to the stratification by gender adjusted by gender + age
| SNP ID | Model | Genotype | Male | Female | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Control | Case | Adjusted analysis | Crude analysis | Control | Case | Adjusted analysis | Crude analysis | |||||||
| OR (95%CI) | p | OR (95%CI) | p | OR (95%CI) | p | OR (95%CI) | p | |||||||
| rs1064607 | Allele | G | 358 (64.4%) | 286 (58.6%) | 1.00 | 0.055 | 130 (61.3%) | 96 (62.3%) | 1.00 | 0.840 | ||||
| C | 198 (35.6%) | 202 (41.4%) | 1.28 (0.99–1.64) | 82 (38.7%) | 58 (37.7%) | 0.96 (0.62–1.47) | ||||||||
| Codominant | G/G | 118 (42.5%) | 78 (32%) | 1.00 | 0.078 | 1.00 | 39 (36.8%) | 33 (42.9%) | 1.00 | 0.370 | 1.00 | |||
| G/C | 122 (43.9%) | 130 (53.3%) | 1.58 (1.04–2.39) | 1.61 (1.10–2.35) | 0.043 | 52 (49.1%) | 30 (39%) | 0.68 (0.35–1.30) | 0.68 (0.36–1.30) | 0.390 | ||||
| C/C | 38 (13.7%) | 36 (14.8%) | 1.54 (0.85–2.80) | 1.43 (0.84–2.45) | 15 (14.2%) | 14 (18.2%) | 1.12 (0.47–2.68) | 1.10 (0.47–2.62) | ||||||
| Dominant | G/G | 118 (42.5%) | 78 (32%) | 1.00 | 0.024 | 1.00 | 0.013 | 39 (36.8%) | 33 (42.9%) | 1.00 | 0.410 | 1.00 | 0.410 | |
| G/C-C/C | 160 (57.5%) | 166 (68%) | 1.57 (1.06–2.33) | 1.57 (1.10–2.25) | 67 (63.2%) | 44 (57.1%) | 0.77 (0.42–1.42) | 0.78 (0.43–1.41) | ||||||
| Recessive | G/G-G/C | 240 (86.3%) | 208 (85.2%) | 1.00 | 0.530 | 1.00 | 0.720 | 91 (85.8%) | 63 (81.8%) | 1.00 | 0.440 | 1.00 | 0.460 | |
| C/C | 38 (13.7%) | 36 (14.8%) | 1.19 (0.69–2.05) | 1.09 (0.67–1.79) | 15 (14.2%) | 14 (18.2%) | 1.38 (0.62–3.08) | 1.35 (0.61–2.99) | ||||||
| Log-additive | – | – | – | 1.32 (1.00–1.74) | 0.053 | 1.29 (1.00–1.66) | 0.052 | – | – | 0.96 (0.63–1.47) | 0.870 | 0.96 (0.63–1.46) | 0.850 | |
| rs3796283 | Allele | A | 332 (59.7%) | 263 (53.9%) | 1.00 | 0.058 | 118 (55.7%) | 92 (59.7%) | 1.00 | 0.440 | ||||
| G | 224 (40.3%) | 225 (46.1%) | 1.27 (0.99–1.62) | 94 (44.3%) | 62 (40.3%) | 0.85 (0.56–1.29) | ||||||||
| Codominant | A/A | 104 (37.4%) | 64 (26.2%) | 1.00 | 0.036 | 1.00 | 30 (28.3%) | 30 (39%) | 1.00 | 0.160 | 1.00 | |||
| G/A | 124 (44.6%) | 135 (55.3%) | 1.76 (1.14–2.71) | 1.77 (1.19–2.63) | 0.017 | 58 (54.7%) | 32 (41.6%) | 0.52 (0.27–1.03) | 0.55 (0.28–1.07) | 0.190 | ||||
| G/G | 50 (18%) | 45 (18.4%) | 1.43 (0.81–2.50) | 1.46 (0.88–2.43) | 18 (17%) | 15 (19.5%) | 0.80 (0.34–1.89) | 0.83 (0.36–1.95) | ||||||
| Dominant | A/A | 104 (37.4%) | 64 (26.2%) | 1.00 | 0.014 | 1.00 | 0.006 | 30 (28.3%) | 30 (39%) | 1.00 | 0.100 | 1.00 | 0.130 | |
| G/A-G/G | 174 (62.6%) | 180 (73.8%) | 1.67 (1.10–2.51) | 1.68 (1.16–2.45) | 76 (71.7%) | 47 (61%) | 0.59 (0.31–1.11) | 0.62 (0.33–1.15) | ||||||
| Recessive | A/A-G/A | 228 (82%) | 199 (81.6%) | 1.00 | 0.980 | 1.00 | 0.890 | 88 (83%) | 62 (80.5%) | 1.00 | 0.680 | 1.00 | 0.660 | |
| G/G | 50 (18%) | 45 (18.4%) | 1.01 (0.61–1.65) | 1.03 (0.66–1.61) | 18 (17%) | 15 (19.5%) | 1.17 (0.55–2.52) | 1.18 (0.55–2.53) | ||||||
| Log-additive | – | – | – | 1.26 (0.96–1.66) | 0.095 | 1.27 (0.99–1.63) | 0.056 | – | – | 0.83 (0.54–1.27) | 0.380 | 0.84 (0.55–1.29) | 0.430 | |
| rs2378456 | Allele | G | 312 (56.3%) | 245 (50.8%) | 1.00 | 0.077 | 107 (50.5%) | 88 (58.7%) | 1.00 | 0.120 | ||||
| C | 242 (43.7%) | 237 (49.2%) | 1.25 (0.98–1.59) | 105 (49.5%) | 62 (41.3%) | 0.72 (0.47–1.09) | ||||||||
| Codominant | G/G | 93 (33.6%) | 58 (24.1%) | 1.00 | 0.100 | 1.00 | 24 (22.6%) | 30 (40%) | 1.00 | 0.022 | 1.00 | |||
| G/C | 126 (45.5%) | 129 (53.5%) | 1.63 (1.04–2.56) | 1.64 (1.09–2.47) | 0.053 | 59 (55.7%) | 28 (37.3%) | 0.37 (0.18–0.76) | 0.38 (0.19–0.76) | 0.023 | ||||
| C/C | 58 (20.9%) | 54 (22.4%) | 1.39 (0.80–2.40) | 1.49 (0.91–2.45) | 23 (21.7%) | 17 (22.7%) | 0.60 (0.26–1.38) | 0.59 (0.26–1.35) | ||||||
| Dominant | G/G | 93 (33.6%) | 58 (24.1%) | 1.00 | 0.041 | 1.00 | 0.017 | 24 (22.6%) | 30 (40%) | 1.00 | 0.012 | 1.00 | 0.012 | |
| G/C-C/C | 184 (66.4%) | 183 (75.9%) | 1.55 (1.02–2.38) | 1.59 (1.08–2.35) | 82 (77.4%) | 45 (60%) | 0.44 (0.23–0.84) | 0.44 (0.23–0.84) | ||||||
| Recessive | G/G-G/C | 219 (79.1%) | 187 (77.6%) | 1.00 | 0.940 | 1.00 | 0.690 | 83 (78.3%) | 58 (77.3%) | 1.00 | 0.830 | 1.00 | 0.880 | |
| C/C | 58 (20.9%) | 54 (22.4%) | 1.02 (0.64–1.62) | 1.09 (0.72–1.66) | 23 (21.7%) | 17 (22.7%) | 1.08 (0.53–2.22) | 1.06 (0.52–2.15) | ||||||
| Log-additive | – | – | – | 1.21 (0.92–1.58) | 0.180 | 1.25 (0.97–1.59) | 0.078 | – | – | 0.73 (0.48–1.11) | 0.140 | 0.72 (0.48–1.10) | 0.130 | |
OR odds ratio, 95% CI 95% confidence interval
Bold indicates statistical signifcance (p < 0.05)