Table 5.
The relationship of seven 3′UTR polymorphisms with lung cancer according to the histology stratification
| SNP ID | Model | Genotype | Control | Adenocarcinoma | Squamous cell carcinoma | Small cell carcinoma | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case | OR (95% CI) | p–value | Case | OR (95% CI) | p–value | Case | OR (95% CI) | p–value | ||||
| rs1064607 | Allele | G | 488 (63.5%) | 169 (56.3%) | 1.00 | 0.030 | 121 (62.7%) | 1.00 | 0.762 | 92 (62.2%) | 1.00 | 0.750 |
| C | 280 (36.5%) | 131 (43.7%) | 1.35 (1.03–1.77) | 73 (37.6%) | 1.05 (0.76–1.46) | 56 (37.8%) | 1.06 (0.74–1.53) | |||||
| Codominant | G/G | 157 (40.9%) | 47 (31.3%) | 1.00 | 0.085 | 37 (38.1%) | 1.00 | 0.760 | 27 (36.5%) | 1.00 | 0.780 | |
| G/C | 174 (45.3%) | 75 (50%) | 1.39 (0.89–2.16) | 47 (48.5%) | 1.22 (0.72–2.07) | 38 (51.4%) | 1.20 (0.69–2.10) | |||||
| C/C | 53 (13.8%) | 28 (18.7%) | 1.90 (1.06–3.42) | 13 (13.4%) | 1.13 (0.52–2.47) | 9 (12.2%) | 0.99 (0.43–2.31) | |||||
| Dominant | G/G | 157 (40.9%) | 47 (31.3%) | 1.00 | 0.053 | 37 (38.1%) | 1.00 | 0.480 | 27 (36.5%) | 1.00 | 0.590 | |
| G/C-C/C | 227 (59.1%) | 103 (68.7%) | 1.50 (0.99–2.28) | 60 (61.9%) | 1.20 (0.73–1.98) | 47 (63.5%) | 1.16 (0.68–1.97) | |||||
| Recessive | G/G-G/C | 331 (86.2%) | 122 (81.3%) | 1.00 | 0.096 | 84 (86.6%) | 1.00 | 0.970 | 65 (87.8%) | 1.00 | 0.780 | |
| C/C | 53 (13.8%) | 28 (18.7%) | 1.57 (0.93–2.66) | 13 (13.4%) | 1.02 (0.49–2.10) | 9 (12.2%) | 0.89 (0.41–1.95) | |||||
| Log-additive | – | – | – | 1.38 (1.04–1.83) | 0.026 | – | 1.10 (0.77–1.58) | 0.590 | – | 1.05 (0.72–1.53) | 0.810 | |
SNP single nucleotide polymorphism, OR odds ratio, 95% CI 95% confidence interval. p values were adjusted by gender and age
Bold indicates statistical signifcance (p < 0.05)