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. 2019 Jan 9;7:7. doi: 10.1186/s40425-018-0467-y

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Specificity of 19305DP TCR. a IFN-γ production from 19305DP-TCR or CD8SP-TCR-transduced CD8⁺ T cells against wild-type or alanine-substituted NY-ESO-1_157-165 peptides at different concentration was investigated by intracellular cytokine staining. b Percentage of relative IFN-γ production on TCR-transduced CD8⁺ T cells against alanine-substituted peptides at peptide concentration of 0.1 μM. Data are represented as % recognition as compared to % IFN-γ-producing CD8⁺ T cells against wild-type NY-ESO-1_157-165 peptide. c 19305DP-TCR-transduced T cells were cocultured with the indicated panel of normal human tissue-derived primary cells or melanoma cell lines for 24 h. Some primary cell lines were pulsed with NY-ESO-1_157-165 peptide (+pep) before coculture. IFN-γ level in the supernatant was measured by ELISA