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. 2018 Oct 3;124(1):94–100. doi: 10.1161/CIRCRESAHA.118.313234

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© 2018 The Authors.

Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 2. — Casp1^−/− microbiota promotes atherosclerosis development in Ldlr^−/− mice fed high-fat cholesterol (HFC) diet. A, Representative toluidine blue stained slides of the aortic root. Scale bars, 400 μm. B, Quantification of atherosclerotic root lesion area. Chow (13 wk): Ldlr^−/−(Ldlr^−/−) mice, n=15; Ldlr^−/−(Casp1^−/−) mice, n=16. HFC (8 wk): Ldlr^−/−(Ldlr^−/−) mice, n=19; Ldlr^−/−(Casp1^−/−) mice, n=19. HFC (13 wk): Ldlr^−/−(Ldlr^−/−) mice, n=14; Ldlr^−/−(Casp1^−/−) mice, n=13. In bar graphs, data represent number of observations. For the scatter plot, the midline represents the mean±SEM. *P<0.05 by unpaired 1-tailed Student t test.