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. 2018 Oct 3;124(1):94–100. doi: 10.1161/CIRCRESAHA.118.313234

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© 2018 The Authors.

Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 4. — Casp1^−/−-induced alterations in the gut microbiota. Female Ldlr^−/− mice were exposed to fecal microbiota derived from Casp1^−/− or Ldlr^−/− mice by means of cohousing for 13 wk while fed chow and high-fat cholesterol (HFC) diet. A–D, Abundance of microbiota taxonomies based on LEfSe analysis of 16S-rDNA (ribosomal DNA)-encoding sequences in feces collected at time of sacrifice. A, Family Akkermansia. B, Genus Christensenellaceae. C, Genus Clostridium. D, Genus Odoribacter. E, Cecum concentration of propionate, acetate, and butyrate in HFC-fed mice. A–D, Chow: Ldlr^−/−(Ldlr^−/−) mice, n=15; Ldlr^−/−(Casp1^−/−) mice, n=14; HFC: Ldlr^−/−(Ldlr^−/−) mice, n=13; Ldlr^−/−(Casp1^−/−) mice, n=14. E, Ldlr^−/−(Ldlr^−/−) mice, n=8; Ldlr^−/−(Casp1^−/−) mice, n=9. Data represent mean±SEM. *P<0.05 as determined by Kruskal-Wallis test (A–D) and unpaired 1-tailed Student t test (E). SCFA indicates short-chain-fatty acid.