Table 5.

Multivariate analysis for the effect of clinicopathologic parameters and RET expression on overall survival

Clinicopathologic parameter	Hazard Ratio (95% CI)	p-value
Age (per 1-year)	1.04 (1.03–1.05)	< 0.0001
Tumour size (pT)	1.29 (1.14–1.45)	< 0.0001
Lymph node involvement (pN)	1.47 (1.25–1.73)	< 0.0001
Tumour grade (BRE)	1.77 (1.50–2.10)	< 0.0001
Intrinsic subtype
Luminal A	1
Luminal B (HER2-negative)	0.96 (0.66–1.39)	0.81
Luminal B (HER2-positive)	1.03 (0.64–1.65)	0.92
HER 2 type	0.86 (0.51–1.45)	0.58
Basal-like	1.43 (0.94–2.18)	0.09
RET expression
RET-positive	1.03 (0.83–1.28)	0.79