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. 2019 Jan 8;20:6. doi: 10.1186/s12863-018-0709-5

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Study sample collection timeline. Colored boxes correspond to data availability of that trait to one of the four viruses. Bovine Viral Diarrhea Virus 1 (BVDV1) in blue, Bovine Viral Diarrhea Virus 2 (BVDV2) in red, Bovine Respiratory Syncytial Virus (BRSV) in green, Bovine Herpesvirus (BHV1) in purple. For each virus 3 response variables were calculated: 1) initial vaccination response = booster titer – initial titer; 2) booster vaccination response = final titer – booster titer; 3) overall vaccination response = final titer – initial titer. For BVDV1 and BVDV2 rate of maternal antibody decay was calculated: (initial titer – maternal titer) / number of days between initial titer and maternal titer measurements)