Table 2.

Most common adverse events

	Grade 1–2		Grade 3		Grade 4
	n	%	n	%	n	%
Hematologic
Neutropenia	10	12.0	19	22.9	9	10.8
Anemia	24	28.9	4	4.8	0	0.0
Thrombocytopenia	1	1.2	0	0.0	0	0.0
Febrile neutropenia	0	0.0	4	4.8	1	1.2
Non-hematologic
Increased ALT concentration	1	1.2	0	0.0	0	0.0
Increased AST concentration	1	1.2	0	0.0	0	0.0
Asthenia/Fatigue	61	73.5	11	13.3	0	0.0
Nausea	46	55.4	4	4.8	0	0.0
Diarrhea	63	75.9	6	7.2	0	0.0
Vomiting	28	33.8	1	1.2	0	0.0
Mucositis	44	53.0	8	9.6	0	0.0
Peripheral edema	2	2.4	0	0.0	0	0.0
Peripheral sensory neuropathy	15	18.1	5	6.0	0	0.0
Dry skin	11	13.2	0	0.0	0	0.0
Left ventricular dysfunction	2	2.4	1	1.2	0	0.0