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. 2019 Jan 8;8:2. doi: 10.1186/s40035-018-0142-8

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Age at onset (AAO) of patients with SOD1 mutations. a Plot of rank ordered SOD1-mutant patients showing the median AAO of 43 years. b Plot comparing the AAO among patients carrying mutations in different exons of the SOD1 gene. Patients (n = 24) harbouring mutations in exon 2 were older than those (n = 18) harbouring mutations in exon 4 (46.63 years vs 37.75, p = 0.002). c Plots comparing fALS patients with sALS patients and (d) plots comparing male patients with female patients; neither comparison identified a significant difference in AAO (p = 0.64 and 0.53, respectively)