Table 2.

Clinical features according to the mutation/variant type in SOD1-mutant patients

*There was one case with missing data. ** There were two cases with missing data

& There was one surviving case. && There were two surviving cases. &&& There were three surviving cases. &&&&& There were five surviving cases

† The interquartile ranges (IQRs) of age at onset and diagnostic delay were calculated and determined to be 38.25–50 years and 6–36.50 months, respectively. Values greater than the third quartile (75%) are highlighted in green, whereas values less than the first quartile (25%) are highlighted in yellow

¶ The disease progression was calculated as ΔFS = (48 - ALS-FRSR at enrolment) / (diagnostic delay in months). Based on references [21] and [22], values less than 0.50 were defined as slow progression and highlighted in green, whereas values greater than 1.00 were defined as fast progression and highlighted in yellow

# For disease duration, there were 61 available cases, and 60% were censored (lost to follow-up or still surviving). Therefore, 25% of the patients survived less than 31 months, and 50% of the patients survived less than 89 months. Values greater than the second quartile (89 months) are highlighted in light green, whereas values less than the first quartile (31 months) are highlighted in yellow