Fig. 1.

mAb A treatment improves ejection fraction and fractional shortening post myocardial infarction (MI). a Schematic of the study design and treatment protocol. Mice were randomised to undergo either sham or left anterior descending (LAD) coronary artery ligation surgery. A week after the surgery, mice in both groups were randomly assigned to receive either saline (vehicle) or mAb A treatment (4 mg kg⁻¹ week⁻¹, s.c.) for 3 weeks. Echocardiographic analysis for sham and MI mice including: b ejection fraction (%), c fractional shortening (%), d end systolic volume (ESV) (µL), e end diastolic volume (EDV) (µL), f tissue doppler E′/A′ and g E/E, h ex vivo cardiac work (joules min⁻¹ g dry wt⁻¹). Data are reported as mean ± SEM. *p < 0.05. n = 12–18