Fig. 4.

mAb A treatment enhances insulin sensitivity, increases glucose oxidation and inhibits fatty acid oxidation post-MI. In ex vivo isolated working hears, the metabolic profile for sham and MI hearts where characterised including measuring a glucose oxidation rates, b palmitate oxidation rates, c β-hydroxybutyrate (β-OHB) oxidation rates and d contribution of each energy substrate to tricarboxylic acid (TCA) cycle acetyl CoA supply, in the presence and absence of insulin. Data are reported as mean ± SEM. *p < 0.05. # indicates significant difference in β-hydroxybutyrate oxidation rates, while @ indicates significant difference in glucose oxidation rates. n = 9–13. S sham, V vehicle, Ab mAb A, MI myocardial infarction