Table 3.
AUROC and pAUROC values for cpRNFL thickness, GCIPL thickness, GCIPL asymmetry measurements, and ONH parameters
| Parameters | AUROC (95% CI) | pAUROC at 90% specificity (95% CI) | pAUROC at 95% specificity (95% CI) |
|---|---|---|---|
| cpRNFL Thickness | |||
| Average | 0.767 (0.685–0.850) | 0.019 (0.004–0.035) | 0.007 (0.000–0.013) |
| Superior | 0.697 (0.605–0.789) | 0.013 (0.000–0.027) | 0.002 (−0.004–0.008) |
| Nasal | 0.523 (0.421–0.622) | 0.007 (−0.004–0.014) | 0.001 (− 0.001–0.005) |
| Inferior | 0.727 (0.639–0.816) | 0.018 (0.002–0.034) | 0.005 (−0.003–0.013) |
| Temporal | 0.676 (0.581–0.770) | 0.012 (0.001–0.023) | 0.005 (0.000–0.009) |
| GCIPL Thickness | |||
| Average | 0.693 (0.604–0.783) | 0.014 (0.004–0.023) | 0.005 (0.000–0.009) |
| Minimum | 0.720 (0.634–0.807) | 0.021 (0.007–0.035) | 0.006 (0.000–0.013) |
| Superonasal | 0.632 (0.537–0.727) | 0.010 (0.001–0.017) | 0.004 (0.001–0.007) |
| Superior | 0.632 (0.537–0.727) | 0.010 (0.002–0.018) | 0.003 (0.000–0.007) |
| Superotemporal | 0.699 (0.610–0.787) | 0.016 (0.003–0.028) | 0.006 (0.001–0.011) |
| Inferotemporal | 0.784 (0.707–0.861) | 0.035 (0.020–0.050) | 0.014 (0.007–0.021) |
| Inferior | 0.695 (0.606–0.784) | 0.020 (0.010–0.030) | 0.010 (0.005–0.014) |
| Inferonasal | 0.614 (0.519–0.710) | 0.007 (−0.001–0.015) | 0.002 (−0.001–0.005) |
| GCIPL Absolute difference | |||
| I–S | 0.628 (0.532–0.724) | 0.023 (0.013–0.034) | 0.011 (0.005–0.016) |
| IT–ST | 0.624 (0.527–0.722) | 0.031 (0.019–0.042) | 0.014 (0.008–0.020) |
| T–N | 0.661 (0.561–0.754) | 0.024 (0.012–0.026) | 0.010 (0.004–0.016) |
| IT–SN | 0.715 (0.626–0.803) | 0.034 (0.021–0.047) | 0.015 (0.009–0.022) |
| IT–IN | 0.704 (0.617–0.790) | 0.023 (0.012–0.033) | 0.010 (0.004–0.015) |
| ST–IN | 0.600 (0.503–0.697) | 0.009 (0.002–0.016) | 0.004 (0.000–0.008) |
| GCIPL Asymmetry Ratio | |||
| I/S | 0.604 (0.507–0.701) | 0.025 (0.013–0.036) | 0.010 (0.005–0.016) |
| IT/ST | 0.606 (0.508–0.703) | 0.028 (0.017–0.040) | 0.013 (0.007–0.018) |
| T/N | 0.684 (0.592–0.776) | 0.033 (0.018–0.047) | 0.014 (0.006–0.022) |
| IT/SN | 0.690 (0.598–0.782) | 0.039 (0.026–0.052) | 0.017 (0.010–0.024) |
| IT/IN | 0.694 (0.603–0.785) | 0.031 (0.018–0.043) | 0.013 (0.007–0.019) |
| ST/IN | 0.610 (0.513–0.708) | 0.013 (0.000–0.026) | 0.035 (−0.001–0.009) |
| GCIPL Asymmetry Index | |||
| Log10 (I/S) | 0.636 (0.540–0.731) | 0.024 (0.012–0.036) | 0.010 (0.004–0.016) |
| Log10 (IT/ST) | 0.651 (0.556–0.747) | 0.036 (0.024–0.048) | 0.017 (0.011–0.023) |
| Log10 (T/N) | 0.678 (0.585–0.770) | 0.026 (0.012–0.041) | 0.010 (0.004–0.016) |
| Log10 (IT/SN) | 0.734 (0.648–0.820) | 0.044 (0.031–0.057) | 0.019 (0.012–0.026) |
| Log10 (IT/IN) | 0.725 (0.641–0.809) | 0.025 (0.013–0.038) | 0.011 (0.005–0.017) |
| Log10 (ST/IN) | 0.624 (0.529–0.720) | 0.010 (0.001–0.019) | 0.004 (0.000–0.008) |
| ONH | |||
| Rim Area | 0.716 (0.626–0.806) | 0.074 (0.004–0.030) | 0.006 (0.000–0.011) |
| Disc Area | 0.636 (0.538–0.734) | 0.005 (−0.004–0.014) | 0.000 (−0.004–0.004) |
| Average C/D | 0.746 (0.662–0.831) | 0.029 (0.013–0.045) | 0.012 (0.004–0.019) |
| Vertical C/D | 0.742 (0.656–0.828) | 0.028 (0.015–0.041) | 0.017 (0.009–0.025) |
| Cup Volume | 0.729 (0.641–0.816) | 0.029 (0.009–0.050) | 0.007 (−0.004–0.018) |
AUROC, area under the receiver operating characteristic curves; pAUROC, partial area under the receiver operating characteristic curves; confidence interval; GCIPL, ganglion cell-inner plexiform layer; cpRNFL, circumferential peripapillary retinal nerve fiber layer; ONH, optic nerve head; CI, confidence interval; C/D, cup-to-disc ratio; I, inferior hemisphere; S, superior hemisphere; IT, inferotemporal; ST, superotemporal; T, temporal; N, nasal; SN, superonasal; IN, inferonasal