Table 4.
Sensitivities at fixed specificities and cutoff values for cpRNFL thickness, GCIPL thickness, GCIPL asymmetry measurements, and ONH parameters
| Parametres | Sensitivity at 90% specificity (%) | Cutoff value* | Sensitivity at 95% specificity (%) | Cutoff value** |
|---|---|---|---|---|
| cpRNFL Thickness | ||||
| Average | 41.7 | 84.5 | 23.3 | 80.5 |
| Superior | 30.0 | 93.5 | 8.3 | 86.5 |
| Nasal | 16.7 | 53.5 | 6.7 | 44.5 |
| Inferior | 46.7 | 100.5 | 26.7 | 92.5 |
| Temporal | 21.7 | 64.5 | 13.3 | 61.5 |
| GCIPL Thickness | ||||
| Average | 23.9 | 72.5 | 10.4 | 70.5 |
| Minimum | 35.8 | 70.5 | 22.3 | 66.5 |
| Superonasal | 11.9 | 72.5 | 9.0 | 70.5 |
| Superior | 16.4 | 72.5 | 9.0 | 70.5 |
| Superotemporal | 34.3 | 72.5 | 20.9 | 71.5 |
| Inferotemporal | 49.3 | 73.5 | 34.3 | 71.5 |
| Inferior | 20.9 | 68.5 | 19.4 | 66.5 |
| Inferonasal | 13.4 | 71.5 | 6.0 | 66.5 |
| GCIPL Absolute difference | ||||
| I–S | 31.3 | 12.5 | 26.9 | 13.5 |
| IT–ST | 38.8 | 4.5 | 32.8 | 6.5 |
| T–N | 29.9 | 14.5 | 23.9 | 15.5 |
| IT–SN | 50.7 | 6.5 | 35.8 | 8.5 |
| IT–IN | 29.9 | 7.5 | 26.9 | 8.5 |
| ST–IN | 10.4 | 8.5 | 10.4 | 10.5 |
| GCIPL Asymmetry Ratio | ||||
| I/S | 31.3 | 0.95 | 28.4 | 0.95 |
| IT/ST | 35.8 | 0.96 | 28.4 | 0.95 |
| T/N | 46.3 | 0.94 | 35.8 | 0.92 |
| IT/SN | 46.3 | 0.92 | 40.3 | 0.91 |
| IT/IN | 37.3 | 0.93 | 34.3 | 0.92 |
| ST/IN | 23.9 | 0.93 | 16.4 | 0.91 |
| GCIPL Asymmetry Index | ||||
| Log10 (I/S) | 32.8 | 0.024 | 29.9 | 0.025 |
| Log10 (IT/ST) | 38.8 | 0.028 | 34.3 | 0.034 |
| Log10 (T/N) | 37.3 | 0.037 | 25.4 | 0.045 |
| Log10 (IT/SN) | 52.2 | 0.036 | 46.3 | 0.040 |
| Log10 (IT/IN) | 29.9 | 0.042 | 26.9 | 0.050 |
| Log10 (ST/IN) | 11.9 | 0.049 | 10.4 | 0.059 |
| ONH | ||||
| Rim Area | 28.4 | 0.945 | 19.4 | 0.885 |
| Disc Area | 13.4 | 2.54 | 3.0 | 2.84 |
| Average C/D | 52.2 | 0.695 | 29.9 | 0.725 |
| Vertical C/D | 50.7 | 0.665 | 41.8 | 0.685 |
| Cup Volume | 52.2 | 0.336 | 29.2 | 0.467 |
AUROC, area under the receiver operating characteristic curves; GCIPL, ganglion cell-inner plexiform layer; cpRNFL, circumferential peripapillary retinal nerve fiber layer; ONH, optic nerve head; C/D, cup-to-disc ratio; I, inferior hemisphere; S, superior hemisphere; IT, inferotemporal; ST, superotemporal; T, temporal; N, nasal; SN, superonasal; IN, inferonasal
*Based on 90% specificity
**Based on 95% specificity