Table 3.

Differences in primary and secondary outcomes at 3 and 12 months

Factor	Standard care	Intervention	Unadjusted mean difference	p-value	Adjusted mean difference	p-value
3 Months change from baseline (outcome – baseline)
Child’s pain assessment, mean (SD)	−1.33 (1.69)	−0.73 (1.55)	0.6 (− 0.02,1.22)	0.058	0.62 (0.04,1.21)	0.038
Parent’s pain assessment mean (SD)	−6.73 (26.26)	−3.27 (28.64)	3.46 (−6.88,13.8)	0.509	3.36 (−7.01,13.72)	0.522
Parent’s reported physical function, mean (SD)	−0.02 (0.38)	0.13 (0.52)	0.15 (−0.02,0.33)	0.088	0.15 (−0.02,0.32)	0.089
Child reported HRQoL, mean (SD)	0.00 (0.10)	0.01 (0.11)	0.01 (−0.03,0.05)	0.493	0.01 (−0.03,0.05)	0.492
Coordination, mean (SD)	7.57 (20.26)	6.21 (19.54)	−1.36 (−8.88,6.16)	0.721	−1.36 (−8.92,6.19)	0.721
Grip strength, mean (SD)	2.32 (12.03)	1.12 (13.87)	−1.2 (−6.18,3.78)	0.634	−1.21 (− 6.19,3.77)	0.632
12 Months change from baseline (outcome – baseline)
Child’s pain assessment, mean (SD)	−1.58 (1.92)	−1.57 (1.53)	0.01 (−0.66,0.69)	0.967	0.06 (−0.6,0.71)	0.862
Parent’s pain assessment mean (SD)	−7.25 (29.50)	−6.81 (27.30)	0.44 (−10.55,11.43)	0.937	−0.08 (−10.94,10.78)	0.988
Parent-reported physical function, mean (SD)	−0.02 (0.38)	0.04 (0.55)	0.06 (−0.12,0.24)	0.522	0.06 (−0.13,0.24)	0.546
Child reported HRQoL, mean (SD)	−0.00 (0.12)	0.02 (0.09)	0.02 (−0.02,0.06)	0.244	0.03 (−0.02,0.07)	0.222
Coordination, mean (SD)	10.75 (19.46)	3.83 (20.75)	−6.92 (−14.76,0.92)	0.083	−6.87 (− 14.75,1.02)	0.087
Grip strength, mean (SD)	7.29 (16.05)	4.72 (17.16)	−2.58 (−9.05,3.89)	0.431	−2.59 (−9.1,3.92)	0.432