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. 2019 Jan 8;20:20. doi: 10.1186/s12864-018-5319-0

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© The Author(s). 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Correlation of fitness scores of S. Typhimurium transposon-insertion mutants in the ileal wall and mesenteric lymph nodes and distribution of fitness scores. (a) A correlation plot showing a high degree of correlation between fitness scores of 8315 transposon-insertion mutants identified in the ileal wall and MLNs suggests that majority of mutants have similar phenotypes in both tissues. (b) Histograms of the fitness scores of mutants in the ileal wall and MLNs show that a large proportion of mutants have fitness scores approximate to zero in both tissues, suggesting that many insertions have no effect on phenotype. Based on fitting of bimodal distributions of fitness scores in the histograms, a fitness score of ≤ − 3.0 was selected as the cut-off value to define attenuation (within the yellow box)