Table 1. Analysis of runs of homozygosity (ROH) in dogs carrying homozygous recessive deleterious mutations. ROH > 0.5 Mb (detected by our ROH analysis) harbor recessive deleterious alleles at minimum 29.8X more than ROH < 0.5 Mb.
| All ROH Tracts** | ROH Harboring SOD1 | ROH Harboring other recessive deleterious mutations | Relative risk compared to ROH < 0.5 Mb | |||||
|---|---|---|---|---|---|---|---|---|
| ROH Length | PLINK | GERMLINE | PLINK | GERMLINE | PLINK | GERMLINE | PLINK | GERMLINE |
| < 0.5 Mb* | 75.9 | 75.1 | 36.4 | 34.3 | 9.9 | 7.8 | 1.0 | 1.0 |
| 0.5 - 2.5 Mb | 4.5 | 4.7 | 19.4 | 18.7 | 14.9 | 14.7 | 25.7 | 29.8 |
| 2.5 - 5.0 Mb | 3.3 | 3.1 | 15.2 | 14.5 | 11.6 | 11.4 | 27.4 | 35.7 |
| > 5.0 Mb | 16.4 | 17.1 | 29.0 | 32.5 | 63.5 | 66.1 | 29.8 | 37.0 |
*
ROH below our detection threshold.
**
Average fraction of genome composed of each tract length category across all dogs.