Fig. 1.

Clearance predictions versus weight (0.5–200 kg) in an example neonatal dataset. (a) Median (solid black line) and 95% confidence interval (dotted line) of 1000 functions of CL_TV versus weight obtained from 1000 bootstrap runs; green dots represent the individual post hoc CL_i estimates of the studied patients. (b) Estimated function of CL_TV versus weight from the original dataset (solid black line) and illustrative set of functions of CL_TV versus weight (grey solid lines) obtained in six (of 1000) separate bootstrap runs; green dots represent the individual post hoc CL_i estimates of patients in the original dataset. Depicted results were obtained using a normalization weight of 2.7 kg. CL_TV clearance for a typical individual, CL_i clearance for individual i