Fig. 2.

Relation between weight and the RSE of both CL_TV and CL_pop in an illustrative neonatal dataset. The solid line represents the RSE of CL_TV predictions from 1000 bootstrap runs, the dotted line represents the RSE of CL_TV predictions obtained from the variance–covariance matrix (Eq. 5), and the red dots represent the RSE of the estimated CL_pop parameter using the corresponding normalization weight, obtained from the covariance step of a single NONMEM run. The vertical tick marks on the bottom of the graph depict the body weights of subjects in the dataset. RSE relative standard error, CL_TV clearance for a typical individual, CL_pop population clearance