Table 2.
Characteristics of the different weight distributions and summary of the simulation results
| Distribution | Geometric mean (kg) | SD on log-scale | Distance between geometric mean and 70 kg (in SD on log-scale) | Median RSE ratio CLpop (Eq. 6) for 70 kg normalization | Covariance step successful with 70 kg normalization (%) | Covariance step successful with geometric mean normalization (%) | Covariate step successful in both normalizations (%) |
|---|---|---|---|---|---|---|---|
| PEDIAT1 Log-normal |
20 | 0.25 | 5.0 | 4.3 | 72 | 57 | 54 |
| PEDIAT2 Uniform 10–32 kg |
20 | 0.33 | 3.9 | 3.5 | 79 | 63 | 59 |
| PEDIAT3 Uniform 1–51 kg |
20 | 0.83 | 1.5 | 1.7 | 85 | 85 | 84 |
| OBESE1 Uniform 110–220 |
162 | 0.2 | − 4.2 | 3.5 | 31 | 32 | 28 |
| OBESE2 Uniform 80–160 |
118 | 0.2 | − 2.6 | 2.3 | 47 | 48 | 45 |
| OBESE3 Uniform 45–160 |
97 | 0.35 | − 0.9 | 1.1 | 52 | 53 | 50 |
RSE relative standard error, SD standard deviation, CLpop population clearance