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. Author manuscript; available in PMC: 2019 Mar 15.
Published in final edited form as: Annu Rev Vis Sci. 2018 Sep 15;4:101–122. doi: 10.1146/annurev-vision-091517-034018

Figure 4:

Figure 4:

Regulation of lipid-metabolism-driven inflammation of pathological neovascularization in the eye via the RORα-SOCS3 pathway. RORα senses lipid metabolites and regulates target gene expression through binding to RORE elements in their promoter region. RORα regulates pathological neovascularization (NV) in the eye via control of tissue inflammation and macrophage polarization. Additional abbreviations: RORa retinoic-acid-receptor-related orphan receptor alpha; RORE, RORα responsive element; SOCS3, suppressor of cytokine signaling 3.