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. 2018 Oct 11;7(2):27–32. doi: 10.1016/j.cr.2018.08.001

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© 2018 Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences. Production and hosting by Elsevier B.V. on behalf of KeAi.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1 — LncRNAs in normal hematopoiesis. Several lncRNAs are involved in the blood cell development. LncHSC-1/2, Xist and H19 regulate HSC quiescence and self-renewal. LinRNA-EPS, alncRNA-EC7 and elncRNA-EC3 modulate red blood cell formation. HOTAIRM1 functions in granulocytic differentiation. EGO promotes eosinophil differentiation. LincRNA-Cox2, NKILA, PACER, and Lethe participate in the innate immune response. NeST correlates to T cell formation. Lnc-DC is essential for dendritic cell differentiation.