Fig. 2.

LncRNAs in malignant hematopoiesis. Some lncRNAs share close relationship with hematopoietic diseases. They act as oncogenic or tumor suppressive lncRNAs. H19 and lncRNA-BGL3 are associated with chronic myeloid leukemia (CML). RUNXOR, PVT1 and IRAIN are involved in acute myeloid leukemia (AML). LUNAR1 acts as an oncogene in T cell acute lymphoblastic leukemia (T-ALL). Morrbid is highly expressed in patients with hypereosinophilic syndrome (HES). NEAT1 expression is repressed in de novo acute promyelocytic leukemia (APL) patients. Similarly, Kawasaki disease patients with severe symptoms show decreased THRIL expression.