Table 1.
Overview of measures throughout the 29-day study duration
| Frame of reference | Time of measurement | Obtained by | |
| Patient-reported outcomes | |||
| Medical questionnaires | |||
| ACT | Last 4 weeks | d1, d29 | Physician* |
| ACT | Last week† | d8, d15, d22, d29 | Smartphone app |
| PSQI | Last 4 weeks | d29 | Study nurse* |
| PSQI | Last night† | d1 – d29 | Smartphone app |
| AQ20 | Momentary | d1, d29 | Smartphone app‡ |
| LCQ | Last 2 weeks | d1, d29 | Smartphone app‡ |
| VAS (severity of nocturnal cough) | Last night | d1 – d29 | Smartphone app |
| VAS (severity of cough by day) | Last day | d1 – d29 | Smartphone app |
| VAS (asthma symptom strength) | This morning | d1 – d29 | Smartphone app |
| Other questionnaires | |||
| Usage habit smartphone app | Momentary | d8, d15, d22, d29 | Smartphone app |
| Technical evaluation questionnaire | Last 4 weeks | d29 | Study nurse |
| Medical control questions | |||
| Occurrence of cold/rhinitis | Last week | d8, d15, d22, d29 | Smartphone app |
| Asthma related events (exacerbations and physician visits) | Last week | d8, d15, d22, d29 | Smartphone app |
| Technical control questions | |||
| Smartphone position overnight | Last days | d3, d14, d24 | Smartphone app |
| Smartphone distance overnight | Last days | d3, d14, d24 | Smartphone app |
| Objective measures | |||
| Lung function assessments | |||
| FEV1 | d1, d29 | Spirometry | |
| FVC | d1, d29 | Spirometry | |
| FEV1/FVC | d1, d29 | Spirometry | |
| FeNO | d1, d29 | NIOX handheld device | |
| Smartphone data | |||
| Microphone | n1 – n28§ | Smartphone app | |
| Accelerometer | n1 – n28§ | Smartphone app | |
| Proximity sensor | n1 – n28§ | Smartphone app | |
| Ambient light sensor | n1 – n28§ | Smartphone app | |
| GPS | n1 – n28§ | Smartphone app | |
| Bluetooth | n1 – n28§ | Smartphone app | |
| Usage data (screen lock status, connection status and battery status) | n1 – n28§ | Smartphone app | |
*In case of non-resolvable appointment scheduling issues on day 29, the participant is instructed to fill out an online version of the questionnaire to ensure parallel measurements between participants.
†The temporal frame of reference for these questionnaires is shortened in comparison with the respective original publication to produce more distinct measurements for each participant, thereby increasing the data resolution for statistical modelling. The question framing and answer options are adapted to the revised frame of reference.
‡If a participant does not respond to the smartphone app questionnaire in the morning of day 29, the questionnaire will be administered by the study nurse during the participant’s study centre visit.
§n1 is the night between day 1 (d1) and day 2 (d2) and so forth.
ACT, Asthma Control Test; AQ20, Asthma Questionnaire 20; FeNO, fractionated exhaled nitric oxide; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; GPS, global positioning system; LCQ, Leicester Cough Questionnaire; PSQI, Pittsburgh Sleep Quality Index; VAS, visual analogue scale.