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. 2019 Jan 9;14(1):e0208118. doi: 10.1371/journal.pone.0208118

Table 2. Impact of side effects of chemotherapy.

Symptoms* Severe Moderate Mild Very mild/None No response
1 Hair loss 883 (59.7%) 339 (22.9%) 139 (9.4%) 97 (6.6%) 20 (1.4%).
2 Fatigue 461 (31.2%) 458 (31.0%) 301 (20.4%) 243 (16.4%) 15 (1.0%)
3 Length of treatment period 427 (28.9%) 457 (30.9%) 336 (22.7%) 235 (15.9%) 23 (1.6%)
4 Anxiety about the disease or treatment 473 (32.0%) 404 (27.3%) 288 (19.5%) 297 (20.1%) 16 (1.1%)
5 Medical expense 483 (32.7%) 393 (26.6%) 274 (18.5%) 312 (21.1%) 16 (1.1%)
6 Taste disorder 441 (29.8%) 334(22.6%) 260 (17.6%) 433 (29.3%) 10 (0.7%)
7 Nail change 381 (25.8%) 368 (24.9%) 320 (21.7%) 397 (26.9%) 12 (0.8%)
8 Burden on family 327 (22.1%) 354 (24.0%) 431 (29.2%) 340 (23.0%) 26 (1.8%)
9 Limb numbness 353 (23.9%) 309 (20.9%) 278 (18.8%) 521 (35.3%) 17 (1.2%)
10 Nausea/Vomiting 300 (20.3%) 291 (19.7%) 230 (15.6%) 641 (43.4%) 16 (1.1%)
11 Depressed mood 239 (16.2%) 352 (23.8%) 338 (22.9%) 528 (35.7%) 21 (1.4%)
12 Weight gain/Edema 281 (19.0%) 278 (18.8%) 264 (17.9%) 640 (43.3%) 15 (1.0%)
13 Frustration caused by not being able to a job or housework 242 (16.4%) 316 (21.4%) 356 (24.1%) 542 (36.7%) 22 (1.5%)
14 Discomfort during infusion 202 (13.7%) 326 (22.1%) 334 (22.6%) 598 (40.4%) 18 (1.2%)
15 Sleep disorder 204 (13.8%) 255 (17.3%) 310 (21.0%) 693 (46.9%) 16 (1.1%)

*Symptoms were ranked by the total percentage of severe and moderate side effects.