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. 2019 Jan 9;14(1):e0209824. doi: 10.1371/journal.pone.0209824

Fig 4. KIRA7 reverses bleomycin-induced fibrosis when given 2 weeks after bleomycin exposure.

Fig 4

(A) Schematic of the KIRA7 reversal regimen. Mice were exposed to saline or bleomycin once, then treated with KIRA7 or vehicle beginning two weeks after bleomycin exposure and continuing daily for two additional weeks. (B) Western blot of terminal UPR transcription factors XBP1s, ATF4, and CHOP from mice treated with KIRA7 according to the reversal regimen. (C) Markers of fibrosis (lung weight, hydroxyproline content, collagen 1A1 mRNA, and fibronectin mRNA) from mice exposed to saline or bleomycin, and treated with KIRA7 according to the reversal regimen. Each mouse is represented by a dot, and whiskers denote group mean +/- SEM. P values: *<0.05, **<0.01, ***<0.001.