. 2019 Jan 9;14(1):e0200967. doi: 10.1371/journal.pone.0200967

Table 2. Outlier and modified effects for Gly allele associations with sports performance.

		Test of association				Test of heterogeneity				Test of association				Test of heterogeneity			Effect of outlier treatment (Fs)
	n	OR	95% CI	P^a	SP	P^b	I² (%)	AM	n	OR	95% CI	P^a	SP	P^b	I² (%)	AM	Significance	Heterogeneity
		PRO								PSO
All	16	1.24	1.08–1.41	0.002 ^*	Fs	0.0006	62	R	14	1.16	1.06–1.26	0.001 ^*	Fs	0.16	27	F	RS	RH
Power	7	1.25	1.08–1.44	0.003 ^*	Fs	0.66	0	F	—	——	——	——	—	—	—	—	—	—
Endurance	11	1.24	1.02–1.51	0.03	Fs	0.0005	68	R	8	1.23	1.08–1.42	0.003	Fs	0.10	41	F	ES	RH
Mixed	6	1.06	0.72–1.55	0.78	Fs	10⁻⁴	83	R	4	1.07	0.88–1.30	0.49	Fs	0.31	16	F	RNS	RH
*Race*
Caucasian	13	1.29	1.12–1.49	0.0005 ^*	Fs	0.002	61	R	11	1.19	1.08–1.31	0.0004 ^*	Fs	0.19	27	F	RS	RH
Asian	3	0.99	0.79–1.24	0.92	Null	0.34	8	F	—	——	——	——	—	—	—	—	—	—
*Modified*
All	10	1.23	1.06–1.44	0.008	Fs	0.001	67	R	8	1.13	1.03–1.25	0.01	Fs	0.53	0	F	RS	EH
All > 80%	5	1.38	1.14–1.66	0.0007 ^*	Fs	0.005	73	R	3	1.19	1.05–1.34	0.007	Fs	0.95	0	F	RS	EH
Power	6	1.22	1.05–1.42	0.008	Fs	0.64	0	F	—	——	——	——	—	—	—	—	—	—
Endurance	7	1.19	0.94–1.51	0.14	Fs	0.001	73	R	6	1.09	0.94–1.25	0.27	Fs	0.15	38	F	RNS	RH
Mixed	4	1.03	0.59–1.78	0.92	Fs	10⁻⁵	89	R	2	1.07	0.84–1.37	0.56	Fs	0.13	57	F	RNS	RH
*Race*
Caucasian	8	1.32	1.13–1.54	0.0005 ^*	Fs	0.009	63	R	6	1.18	1.06–1.32	0.003	Fs	0.78	0	F	RS	EH
Asian	2	0.99	0.72–1.99	0.53	Null	0.46	0	F	—	——	——	——	—	—	—	—	—	—

n: number of studies; Modified: ≥ 248 sample size in either case or control; All > 80%: studies with ≥ 248 participants in case and in control; PRO: pre-outlier; PSO: post outlier; OR: odds ratio; CI: confidence interval; P^a: P-value for association

* P^a values that survived the Bonferroni correction; P^b: P-value for heterogeneity; AM: analysis model; R: random-effects; F: fixed-effects; SP: sports performance; Fs: favor SP; ORs = 0.99–1.01 were considered null; RS: retained significance; RNS: retained non-significance; ES: elevated significance; RH: reduced heterogeneity; EH: eliminated heterogeneity. Values in bold indicate significant associations that favor SP only.