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. 2019 Jan 9;14(1):e0207422. doi: 10.1371/journal.pone.0207422

Fig 4. TLR3 deficiency dysregulates the Chlamydia-induced gene expression of the claudin integral membrane tight junction (TJ) proteins.

Fig 4

Gene expression levels of Claudins 1–4 were measured by qPCR at various times post-infection in C. muridarum infected WT, TLR3-deficient, and TLR3-deficient OE cells that were pre-treated with 50U/ml recombinant IFN-β 1hr before infection. Data are representative of three or more independent experiments. OE-129WT = wild-type and OE-TLR3(-) = TLR3-deficient OE cells. The data are represented as mean (SD). * = p <0.05, ** = p <0.005, and *** = p <0.001 when compared to TLR3-deficient OE cells at the given time.