Table 1. Dynamic Enantioselective Addition of Organozinc to Aromatic Aldehydes with (R)-1.

^aGeneral reaction conditions: 0.0125 mmol of (R,P,S_a/R_a)-1 in 0.5 mL of dry toluene at 0 °C; 0.375 mmol of R₂Zn (Et₂Zn, 1.0 M in hexane; i-Pr₂Zn, 1.0 M in toluene) added dropwise and stirred over 10 min; 0.125 mmol of 11 added to the mixture. Reaction mixture stirred for 7 d at 0 °C. Reaction with irradiated mixture of (R)-1: 0.00125 mmol of (R,P,S_a/R_a)-1 in 15 mL of dry, degassed Et₂O, irradiated with UV light (365 nm) for 30 min until the PSS was reached (S:MS = 17:83). PSS ratio determined by chiral HPLC analysis. Reaction procedure follows as described above.

^bDetermined by ¹H NMR analysis of crude.

^cDetermined by chiral GC or chiral HPLC analysis of isolated product.

^dIsolated yield. Abbreviations: N.A., Not Applicable.