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Our proposed “toxin relay” model that explains the slow wash-off feature of DkTx. DkTx is represented by a dumbbell-shaped object with its two ellipses denoting the two knots of the toxin. The knots of the toxin molecules that do not bind to the channel are depicted as empty ellipses and those that bind to the channel as filled ellipses. The wavy blue curves depict buffer flow.
