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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Trends Immunol. 2018 Jul 11;39(8):644–655. doi: 10.1016/j.it.2018.06.001

Figure II:

Figure II:

Major type of DBS breaks. Simple DSBs involve two broken DNA ends (i.e. two-ended DSB) in close proximity. Complex DSBs consist in two broken DNA ends in proximity to additional DNA damage (i.e., cross-links, single stranded breaks, etc...) or a DSB within a replication fork (one-ended DSB).