Table 2. Genotype frequencies of IL-1B gene polymorphisms in colorectal cancer cases and controls.

Models	Genotype	Case (n, %)	Control (n, %)	OR (95% CI)	P-value	Adjusted OR (95% CI)*	P-value
rs1143623
Co-dominant	GG	306 (58.1%)	329 (51.5%)	1.00(reference)	-	1.00(reference)	-
Heterozygote	GC	188 (35.7%)	251 (39.3%)	0.81(0.63,1.03)	0.083	0.76(0.47,1.22)	0.256
Homozygote	CC	32 (6.1%)	57 (8.9%)	0.60(0.38,0.96)	0.032	0.61(0.38,0.97)	0.036
Dominant	GG	306 (58.1%)	329 (51.5%)	1.00(reference)	-	1.00(reference)	-
	GC+CC	220 (41.7%)	308 (48.2%)	0.77(0.61,0.97)	0.026	0.77(0.61,0.97)	0.026
Recessive	GC+GG	494 (93.7%)	580 (90.8%)	1.00(reference)	-	1.00(reference)	-
	CC	32 (6.1%)	57 (8.9%)	0.66(0.42,1.03)	0.069	0.84(0.66,1.08)	0.183
Allele	G	800 (75.9%)	909 (71.1%)	1.00(reference)	-
	C	252 (23.9%)	365 (28.6%)	0.78(0.65,0.95)	0.011
Rs1143634
Co-dominant	CC	399 (75.7%)	447 (70.0%)	1.00(reference)	-	1.00(reference)	-
Heterozygote	CT	119 (22.6%)	168 (26.3%)	0.79(0.61,1.04)	0.094	0.79(0.60,1.04)	0.089
Homozygote	TT	8 (1.5%)	22 (3.4%)	0.41(0.18,0.93)	0.032	0.41(0.18,0.94)	0.036
Dominant	CC	399 (75.7%)	447 (70.0%)	1.00(reference)	-	1.00(reference)	-
	CT+TT	127 (24.1%)	190 (29.7%)	0.75(0.58,0.97)	0.031	0.75(0.58,0.97)	0.030
Recessive	CT+CC	518 (98.3%)	615 (96.2%)	1.00(reference)	-	1.00(reference)	-
	TT	8 (1.5%)	22 (3.4%)	0.43(0.19,0.98)	0.044	0.44(0.19,1.00)	0.049
Allele	C	917 (87.0%)	1062 (83.1%)	1.00(reference)	-
	T	135 (12.8%)	212 (33.2%)	0.74(0.58,0.93)	0.010

*Adjusted for sex and age. Bold values are statistically significant (P < 0.05)